Depression is more than just feeling sad—it’s a serious medical condition that affects nearly 48 million American adults, representing approximately 18.3% of the U.S. population as of late 2025. . When traditional antidepressants and therapy haven’t provided the relief you need, it’s time to explore advanced treatment options.
At HOPE Therapeutics, we specialize in innovative therapies for depression that offer new hope for those living with treatment-resistant depression. Our comprehensive approach includes three evidence-based treatment modalities backed by science, each working through different mechanisms to help restore your mental health and quality of life.
We offer:
You may have treatment-resistant depression if:
You’re not alone.
Approximately 30% of people with major depression don’t respond adequately to traditional antidepressants. That’s why we offer specialized treatments designed specifically for treatment-resistant depression.
Each of our depression treatments works differently and offers unique benefits. During your consultation, we’ll help you determine which approach—or combination of approaches—is right for you.

Rapid-acting infusion therapy that promotes neural regeneration and can provide relief within 24-72 hours for severe depression.

FDA-approved nasal spray specifically for treatment-resistant depression, offering rapid relief with established protocols

Non-invasive magnetic brain stimulation that activates underactive brain regions without medications or systemic side effects.
IV Ketamine Therapy has emerged as one of the most promising treatments for severe depression, especially when other treatments have failed. Administered intravenously in our medical office, ketamine works by targeting the brain’s glutamate system—a completely different mechanism than traditional antidepressants.
During treatment, you’ll relax in a comfortable chair while receiving the infusion. You may experience mild dissociation or a dream-like state, which is temporary and resolves shortly after treatment. A medical professional monitors you throughout, and you’ll need someone to drive you home afterward.
Repetitive Transcranial Magnetic Stimulation (rTMS) is an FDA-cleared, non-invasive treatment that uses magnetic pulses to stimulate specific areas of the brain involved in mood regulation. Unlike medications, rTMS directly activates underactive brain regions without systemic side effects.
You’ll sit in a comfortable chair while a magnetic coil is positioned against your scalp. You’ll feel a tapping sensation and hear clicking sounds during treatment. There’s no sedation required—you can read, listen to music, or relax. You can drive yourself to and from appointments and immediately return to your normal activities.
SPRAVATO® (esketamine) is the first and only FDA-approved nasal spray specifically indicated for treatment-resistant depression and for MDD with acute suicidal ideation or behavior. Like IV ketamine, it targets the glutamate system but is administered as a simple nasal spray under medical supervision.
You’ll self-administer the nasal spray under our supervision (3 devices, 5 minutes apart), then rest comfortably in our treatment room for a mandatory 2-hour observation period. We monitor your vital signs and symptoms throughout. You may experience dissociation, dizziness, or sedation during this time. You’ll need someone to drive you home, and you cannot drive until the next day.



Choosing the right depression treatment depends on several factors. Here’s a guide to help you understand which option might be best for your situation:
Schedule a consultation. We’ll review your history, discuss your goals, and recommend the treatment approach most likely to help you achieve lasting relief.
Our team specializes in treatment-resistant depression with extensive training in advanced therapies. We’re certified providers for SPRAVATO®, rTMS, and IV ketamine.
We don’t believe in one-size-fits-all treatment. During your consultation, we’ll evaluate your unique situation and recommend the best approach.
Having three distinct treatment modalities allows us to find the right fit for your needs, preferences, and medical history.
Our care extends beyond the procedure room. We offer medication management, therapy referrals, and ongoing monitoring.
All treatments are performed in our modern facility with state-of-the-art equipment and continuous medical supervision.
We work with most major insurance providers and help navigate coverage, prior authorizations, and payment options.
“After 15 years of depression and trying every antidepressant my doctor could prescribe, I finally found relief with IV ketamine at HOPE Therapeutics. Within a week, I felt like myself again.” — Michael R.
“rTMS changed my life. No more medication side effects, no more feeling numb. Just genuine improvement in my depression. I can’t believe I waited so long to try it.” — Sarah L.
“SPRAVATO® was the breakthrough I needed. My doctor recommended it after two antidepressants didn’t work, and my insurance covered it. The staff made me feel safe and supported throughout.” — Jennifer M.
During your consultation, we’ll discuss the pros and cons of each option based on your specific situation, medical history, and preferences.
Coverage varies by insurance and treatment type. rTMS and SPRAVATO® are often covered for treatment-resistant depression. IV ketamine coverage varies. We’ll verify your benefits before starting.
Depression doesn’t have to control your life. With advanced treatments like IV ketamine therapy, rTMS, and SPRAVATO®, there’s hope even when traditional treatments have failed.
Our compassionate team is here to answer your questions and help you find the treatment that’s right for you. Don’t wait another day. Real relief is possible.
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Effective Date: Jan 1st, 2026
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Effective Date: Jan 1st, 2026
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